Week 15 features a Saturday showdown between two of the hottest teams in the NFL as the Indianapolis Colts host the New England Patriots at Lucas Oil Stadium.
Oddsmakers are predicting a close contest with NFL betting lines opening the Colts as slim 1.5-point favorites before sliding to -2.5.
Here are our best free Patriots vs. Colts NFL picks and predictions for Saturday, December 18, with kickoff at 8:15 p.m. ET.